Take the Fat Quarter of fabric you've chosen for the appliqués and press the paper-backed fusible web to the reverse following the manufacturer's instructions.
You will mark your numbers and dots on this paper surface and cut them out afterwards.
Trace 21 dots - a quarter or button works great.
For the numbers, I drew 6 : 3"x3" squares on the paper to serve as a size guide. Sketch out #s 1-6 BACKWARDS, because you are dealing with the reverse of the fabric and will be fusing this to the RS to the cube.